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Synthesis and Characterization of Biocompatible Polyesteramides: PNOBDME(C34H38N2O6)n and PNOBEE (C26H22N2 O6)n as Cholesteric Liquid Crystals

New polyesteramides, poly[oxy(1,2-dodecane)-oxy-carbonyl-1,4-phenylene-aminecarbonyl-1,4-phenylene-carbonyl-amine-1,4-phenylene-carbonyl]: (C34H38N2 O6 ) n , named PNOBDME, and poly[oxy(1,2-buthylene)-oxy-carbonyl-1,4-phenylene-amine-carbonyl1,4-phenylene-carbonyl-amine-1,4-phenylene-carbonyl]: [C26H22N2 O6 ) n , named PNOBEE, have been designed and synthetized as cholesteric liquid crystal. Both have been fully characterized by 1 H and 13C-NMR, COSY and HSQC and compared to their precursor polyesters PTOBDME and PTOBEE. The thermal behaviour of the new compounds is studied by TG and DSC analysis. Their optical activity is evaluated by optical rotatory dispersion (ORD). Molecular models of the new polymer show helical polymeric chains. Morphology of the samples is also reported by ESEM. The synthetic cholesteric liquid crystal polyestereamides described here have proved to be biocompatible and to act as non-viral vectors in Gene Therapy, transfecting DNA to the nucleus cell.


Mercedes Pérez Méndez

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